This error must have been related to either my attempt at disabling interrogate (maybe dtool wasn’t cleaned?).
I suppose I can look into the original error more if you are interested, but for now with python/interrogate enabled I have a complete build.
Thanks for the heads up on the OPTIMIZE setting but 1 is intended since I’m statically linking panda to my app and I want as much debugging as possible until I push out a final build. 